Ramya made her acting debut in the 2003 Kannada-language film Abhi, alongside Puneet Rajkumar, following which, she acted in many Kannada films, enacting the lead female role and establishing herself as one of the most sought-after actresses in the Kannada film industry.
In 2004, Spandana debuted in the Tamil film industry, also under the name Ramya, with the film Kuththu alongside Silambarasan Rajendar, which managed only a mediocre run at the box office as did her next Tamil film Giri. Her debut film, however, gave her the name ‘Kuthu’ Ramya, by which she was then popularly known in Tamil Nadu. She had two releases in Kannada as well, Ranga S. S. L. C. and Kanti, out of which the latter, a love story set against the backdrop of borders and language issues, was declared a major success. In 2005 she had four releases, all being Kannada films, with the latter three films Aakash, Gowramma and Amrithadhare becoming major box-office successes, whilst also garnering critical acclaim for Ramya’s performance and establishing her as a leading actress in Karnataka.
Her first 2008 release, the Kannada film Mussanjemaatu with Sudeep, was a big hit, for which she also received a nomination for a Best Actress Award at the 56th Filmfare Awards South. Later that year, she starred in the films Bombaat and Anthu Inthu Preethi Banthu. Her final release in 2008 was Gautham Menon’s Vaaranam Aayiram for which she changed her screen name to her actual name Divya again, which is believed to have brought her more luck. She had also dubbed in her own voice for Vaaranam Aayiram, which became a high critical as well as commercial success. She didn’t have any releases in 2009, since both her films Bhimoos Bang Bang Kids and Jothegaara got delayed heavily due to financial problems.
Her first release of 2010 Just Math Mathalli which released on January 26th, 2010 was a huge success and it also received rave reviews. Her role in the film was also very much appreciated. She is currently shooting for Singam Puli opposite Jeeva and Kadhal 2 Kalyanam alongside a newcomer Sathya in Tamil and Kicha-Hucha, Sanju weds Geeta opposite Srinagar Kitty and the comedy drama Siddalingu, in which she portrays the role of a school teacher.
She is also the brand ambassador for Royal Challengers Bangalore.